iSight telephony
I really, really want my Mac to be a telephone.
I realize it's a bit inelegant -- an entire Mac to serve the same purpose as an itty bitty phone. But I see some real benefits, like integration with contact management, call tracking database and more.
It's already been established that Apple's new iSight Webcam for iChat AV works with apps other than iChat AV, so I'm desperately hoping that someone out there is working on something to make this happen.